Neurologic manifestations of podophyllin toxicity

Neurology. 1982 Mar;32(3):308-11. doi: 10.1212/wnl.32.3.308.


A young woman presented with podophyllin intoxication following topical application of podophyllin resin to genital condylomata acuminata. The disorder was marked by hallucinatory psychosis, bone marrow depression, and mild hepatic dysfunction. The psychosis and systemic disturbances resolved within 3 weeks, but were followed by autonomic and sensorimotor peripheral neuropathy. This case illustrates the transient central neurotoxicity and persistent peripheral neurotoxicity of podophyllin.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Autonomic Nervous System Diseases / chemically induced
  • Condylomata Acuminata / drug therapy
  • Delusions / chemically induced
  • Female
  • Genital Neoplasms, Female / drug therapy
  • Hallucinations / chemically induced
  • Humans
  • Nervous System Diseases / chemically induced*
  • Neural Conduction / drug effects
  • Podophyllin / poisoning*
  • Podophyllin / therapeutic use
  • Psychoses, Substance-Induced / etiology


  • Podophyllin