Cerebellar atrophy in epilepsy and headache: lack of relationship to phenytoin

Neurology. 1982 Aug;32(8):910-2. doi: 10.1212/wnl.32.8.910.

Abstract

CT scans of 70 patients with seizures and 48 patients with headaches were studied. Using accepted CT criteria for the diagnosis of cerebellar atrophy, the films were analyzed in a blind, unbiased fashion to evaluate possible relationship between cerebellar atrophy and phenytoin use or epilepsy itself. We found no evidence that either phenytoin or epilepsy caused cerebellar atrophy.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Adolescent
  • Adult
  • Atrophy
  • Cerebellum / diagnostic imaging
  • Cerebellum / pathology*
  • Epilepsy / pathology*
  • Female
  • Headache / pathology*
  • Humans
  • Male
  • Phenytoin / adverse effects*
  • Tomography, X-Ray Computed

Substances

  • Phenytoin