[Effect of clonazepam on neuronal activity in the sensomotor cortex of rat brain]

Farmakol Toksikol. Nov-Dec 1978;41(6):674-6.
[Article in Russian]

Abstract

In tests on flaxedyl immobilized rats the effect of clonazepam on the action produced by gamma-aminobutyric acid, acetylcholine and L-glutamate, delivered microionophoretically to neurons of the sensomotor brain cortex, was investigated. Clonazepam was found to potentiate the inhibiting action of gamma-aminobutyric acid and reduce the exciting effect of acetylcholine and L-glutamate on the spontaneous neuronal activity. The ability of clonazepam, like other tranquilizers of the benzodiazepine series, to augment the sensitivity of the receptive neurons formations to gamma-aminobutyric acid and also influence the ionic permeability of the post-synaptic membrane is suggested.

Publication types

  • Comparative Study
  • English Abstract

MeSH terms

  • Acetylcholine / antagonists & inhibitors
  • Animals
  • Benzodiazepinones / pharmacology*
  • Clonazepam / pharmacology*
  • Drug Interactions
  • Excitatory Amino Acid Antagonists
  • Motor Cortex / drug effects*
  • Rats
  • Somatosensory Cortex / drug effects*
  • gamma-Aminobutyric Acid / pharmacology

Substances

  • Benzodiazepinones
  • Excitatory Amino Acid Antagonists
  • gamma-Aminobutyric Acid
  • Clonazepam
  • Acetylcholine