[Clearance and transformation of inosine in the body]

Farmakol Toksikol. 1978 Nov-Dec;41(6):714-9.
[Article in Russian]

Abstract

In 5 patients with myocardial infarction the ways of the inosine transformation and its clearance rate following injection of this drug in an amount of 200 to 400 mg were studied. After inosine introduction into the organism it is shown to immediately break down to hypoxanthine which makes determination of its half-time body retention period practically impossible. The half-time body retention period for hypoxanthine was about 3 min. The beneficial influence of inosine on the myocardium is apparently due to stimulation of some glycolysis reactions and pentosophosphate shunt at the expense of riboso-1-phosphate.

Publication types

  • English Abstract

MeSH terms

  • Aged
  • Amidophosphoribosyltransferase / metabolism
  • Biotransformation
  • Female
  • Humans
  • Hypoxanthines / biosynthesis
  • Inosine / metabolism*
  • Male
  • Metabolic Clearance Rate
  • Middle Aged
  • Myocardial Infarction / metabolism*
  • Myocardium / metabolism
  • Purine Nucleotides / biosynthesis
  • Ribosemonophosphates / biosynthesis

Substances

  • Hypoxanthines
  • Purine Nucleotides
  • Ribosemonophosphates
  • Inosine
  • Amidophosphoribosyltransferase