Protective effects of ketogenic diets on signs of hypoglycemia

Diabetes. 1978 Nov;27(11):1087-91. doi: 10.2337/diab.27.11.1087.


The effects of diet-induced ketosis on the signs of hypoglycemia were investigated. Lard, medium chain triglycerides, or 1,3-butylene glycol comprised 43% of the diet fed to mice. The diet containing lard or medium chain triglycerides greatly protected the animals from the manifestations of acute insulin-induced hypoglycemia. Furthermore, both diets protected the animals from the effects of repeated insulin injections (every eight hours) for 10 days. In contrast, 1,3-butylene glycol had no protective effects. These experiments suggest that ketogenic diets may be of value in the treatment of recurrent hypoglycemic conditions.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Acidosis / metabolism*
  • Animals
  • Blood Glucose / metabolism
  • Body Weight
  • Dietary Fats*
  • Female
  • Hypoglycemia / physiopathology*
  • Insulin / pharmacology
  • Ketone Bodies / blood*
  • Ketosis / chemically induced
  • Ketosis / metabolism*
  • Mice
  • Triglycerides / pharmacology


  • Blood Glucose
  • Dietary Fats
  • Insulin
  • Ketone Bodies
  • Triglycerides