Vasopressin analogs that antagonize antidiuretic responses by rats to the antidiuretic hormone

Science. 1981 Apr 3;212(4490):49-51. doi: 10.1126/science.7209515.

Abstract

Four new synthetic analogs of vasopressin (antidiuretic hormone) can antagonize the antidiuretic response to intravenous vasopressin in anesthetized, water-loaded rats. They also cause a diuresis resembling that of diabetes insipidus when given intraperitoneally to conscious rats. Such antagonists may prove to be useful both pharmacologically and therapeutically.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Arginine Vasopressin / analogs & derivatives*
  • Arginine Vasopressin / chemical synthesis
  • Arginine Vasopressin / pharmacology
  • Diuresis / drug effects*
  • Female
  • Osmolar Concentration
  • Rats
  • Structure-Activity Relationship
  • Vasopressins / antagonists & inhibitors*

Substances

  • Vasopressins
  • Arginine Vasopressin
  • argipressin, beta-mercapto beta,beta-cyclopentamethylenepropionic acid(1)-O-methyl-Tyr(2)-Val(4)-
  • 1-(beta-mercapto-beta,beta-cyclopentamethylenepropionic acid)-2-(O-ethyl-Tyr)-4-Val-arginine vasopressin