Abstract
Four new synthetic analogs of vasopressin (antidiuretic hormone) can antagonize the antidiuretic response to intravenous vasopressin in anesthetized, water-loaded rats. They also cause a diuresis resembling that of diabetes insipidus when given intraperitoneally to conscious rats. Such antagonists may prove to be useful both pharmacologically and therapeutically.
Publication types
-
Research Support, U.S. Gov't, P.H.S.
MeSH terms
-
Animals
-
Arginine Vasopressin / analogs & derivatives*
-
Arginine Vasopressin / chemical synthesis
-
Arginine Vasopressin / pharmacology
-
Diuresis / drug effects*
-
Female
-
Osmolar Concentration
-
Rats
-
Structure-Activity Relationship
-
Vasopressins / antagonists & inhibitors*
Substances
-
Vasopressins
-
Arginine Vasopressin
-
argipressin, beta-mercapto beta,beta-cyclopentamethylenepropionic acid(1)-O-methyl-Tyr(2)-Val(4)-
-
1-(beta-mercapto-beta,beta-cyclopentamethylenepropionic acid)-2-(O-ethyl-Tyr)-4-Val-arginine vasopressin