Structure-activity relationships in the inhibitory effects of ellipticines on benzo(a)pyrene hydroxylase activity and 3-methylcholanthrene mutagenicity

Biochem Pharmacol. 1980 Dec;29(24):3231-7. doi: 10.1016/0006-2952(80)90296-8.
No abstract available

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Alkaloids / pharmacology*
  • Animals
  • Aryl Hydrocarbon Hydroxylases / antagonists & inhibitors*
  • Benzopyrene Hydroxylase / antagonists & inhibitors*
  • Cytochrome P-450 Enzyme System / metabolism
  • Ellipticines / metabolism
  • Ellipticines / pharmacology*
  • In Vitro Techniques
  • Male
  • Methylcholanthrene / antagonists & inhibitors*
  • Microsomes, Liver / metabolism
  • Mutagens*
  • Rats
  • Structure-Activity Relationship

Substances

  • Alkaloids
  • Ellipticines
  • Mutagens
  • Methylcholanthrene
  • Cytochrome P-450 Enzyme System
  • Benzopyrene Hydroxylase
  • Aryl Hydrocarbon Hydroxylases