Clinical state, plasma levels of haloperidol and prolactin: a correlation study in chronic schizophrenia

Br J Psychiatry. 1980 Dec:137:518-21. doi: 10.1192/bjp.137.6.518.


Chronic schizophrenic patients were maintained for six months on a dosage of haloperidol adjusted to give optimum clinical effect. A correlation was found between extrapyramidal symptoms and prolactin levels and also between plasma haloperidol concentration and plasma prolactin levels. Estimation of plasma prolactin would be a reliable measurement of patients' compliance with medication.

MeSH terms

  • Basal Ganglia Diseases / chemically induced
  • Chronic Disease
  • Female
  • Haloperidol / adverse effects
  • Haloperidol / blood*
  • Haloperidol / therapeutic use
  • Humans
  • Middle Aged
  • Prolactin / blood*
  • Schizophrenia / blood*
  • Schizophrenia / drug therapy


  • Prolactin
  • Haloperidol