The nucleus reticularis lateralis: a region highly sensitive to clonidine

Eur J Pharmacol. 1981 Jan 29;69(3):389-92. doi: 10.1016/0014-2999(81)90490-8.


Slow bilateral microinjections of a low dose of clonidine (75 ng/kg) in the cat's nucleus reticularis lateralis (NRL) lead to significant hypotension and bradycardia. This finding confirms the existence of a ventromedullary highly sensitive site of action of clonidine. It is suggested that clonidine inhibits some vasopressive and cardioacceleratory structures within the NRL region.

MeSH terms

  • Animals
  • Blood Pressure / drug effects
  • Cats
  • Clonidine / administration & dosage
  • Clonidine / pharmacology*
  • Female
  • Heart Rate / drug effects
  • Male
  • Medulla Oblongata / drug effects*
  • Medulla Oblongata / physiology
  • Microinjections


  • Clonidine