The effect of steroidal and nonsteroidal anti-inflammatory agents on corneal re-epithelialization

Invest Ophthalmol Vis Sci. 1981 May;20(5):688-91.

Abstract

Topical 0.5% indomethacin, 0.01% flurbiprofen, 1% prednisolone acetate, 0.1% dexamethasone, or 0.1% fluorometholone pretreatment and daily instillation did not affect the course of re-epithelialization after partial corneal epithelial denudation. However, topical 1% prednisolone acetate, 0.1% dexamethasone, and 0.1% fluorometholone--but not 0.5% indomethacin and 0.01% flurbiprofen--significantly retarded re-epithelialization after complete corneal denudation.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Anti-Inflammatory Agents / pharmacology*
  • Cornea / drug effects*
  • Dexamethasone / pharmacology
  • Epithelium / drug effects
  • Fluorometholone / pharmacology
  • Flurbiprofen / pharmacology
  • Indomethacin / pharmacology
  • Prednisolone / pharmacology
  • Rabbits

Substances

  • Anti-Inflammatory Agents
  • Flurbiprofen
  • Dexamethasone
  • Prednisolone
  • Fluorometholone
  • Indomethacin