Cutaneous alternariosis treated with miconazole

Arch Dermatol. 1981 May;117(5):292-4. doi: 10.1001/archderm.117.5.292.


A 40-year-old man had had a chronic, slowly spreading inflammatory process in the skin over the right knee of ten years' duration. Culture of a biopsy specimen grew Alternaria sp. Antimycotic susceptibility testing with flucytosine, amphotericin B, and miconazole nitrate was performed. The Alternaria was highly sensitive to the last two drugs. Miconazole nitrate, 1.2 g daily intravenously for 31 days, did not induce a clinical response. The lesions were then infiltrated with 10 mg of miconazole nitrate in 10 mL of polyethoxylated castor oil (Cremophor EL) twice weekly, with clearing of the lesions during a several-month period.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Alternaria / isolation & purification
  • Dermatomycoses / drug therapy*
  • Dermatomycoses / microbiology
  • Humans
  • Imidazoles / therapeutic use*
  • Male
  • Miconazole / therapeutic use*


  • Imidazoles
  • Miconazole