The anticoagulant activity of dermatan sulphates: evidence against the involvement of antithrombin III

Br J Pharmacol. 1981 Jan;72(1):81-8. doi: 10.1111/j.1476-5381.1981.tb09108.x.

Abstract

Anticoagulant activity of dermatan sulphates is unaffected by antiserum specific for antithrombin III (AT III) unless the glycosaminoglycan preparation contains demonstrable heparin. 2 Only dermatan sulphate preparations of considerable heparin content potentiate AT III inhibition of thrombin, factor Xa and plasmin. 3 These data suggest that dermatan sulphates exert anticoagulant activity which, unlike that of heparin, is largely or totally independent of AT III.

MeSH terms

  • Animals
  • Anticoagulants / pharmacology*
  • Antithrombin III / physiology*
  • Cattle
  • Chondroitin / analogs & derivatives*
  • Dermatan Sulfate / pharmacology*
  • Heparin / physiology
  • Immune Sera / pharmacology
  • Protease Inhibitors / pharmacology
  • Swine
  • Thrombin Time

Substances

  • Anticoagulants
  • Immune Sera
  • Protease Inhibitors
  • Dermatan Sulfate
  • Antithrombin III
  • Heparin
  • Chondroitin