Spontaneous regression of metastases of renal cancer: A report of two cases including the first recorded regression following irradiation of a dominant metastasis and review of the world literature

Cancer. 1981 Apr 15;47(8):2102-6. doi: 10.1002/1097-0142(19810415)47:8<2102::aid-cncr2820470833>3.0.co;2-k.


Two cases of spontaneous regression of lung metastases are presented. One is the first report of regression of metastases after irradiation of a dominant metastasis. The world literature is reviewed, and 67 documented cases have been found including the two now reported. Attention is drawn to the use of immunotherapy in the treatment of advanced renal cancer.

Publication types

  • Case Reports
  • Comparative Study

MeSH terms

  • Adenocarcinoma / pathology
  • Aged
  • Bone Neoplasms / pathology
  • Bone Neoplasms / secondary
  • Female
  • Humans
  • Kidney Neoplasms / pathology*
  • Kidney Neoplasms / radiotherapy
  • Kidney Neoplasms / surgery
  • Lung Neoplasms / diagnostic imaging
  • Lung Neoplasms / pathology
  • Lung Neoplasms / secondary*
  • Male
  • Middle Aged
  • Neoplasm Regression, Spontaneous*
  • Nephrectomy
  • Radiography
  • Time Factors