Free-radical oxidation (peroxidation) products in serum and synovial fluid in rheumatoid arthritis

J Rheumatol. Mar-Apr 1981;8(2):233-45.


Free-radical oxidation (peroxidation) products were measured in (a) 65 synovial effusions and (b) 30 sera from normal subjects and 58 sera from patients with rheumatoid arthritis (RA). Free-radical oxidation products were detectable in 90% of synovial fluids, their concentration being higher in "inflammatory" than in "degenerative" joint disease. Free-radical oxidation products in serum were significantly elevated in patients with RA compared to normal controls; the levels declined after treatment with a variety of antiinflammatory agents.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Aged
  • Arthritis, Rheumatoid / metabolism*
  • Blood / metabolism*
  • Copper / metabolism
  • Female
  • Fluorescence
  • Free Radicals
  • Humans
  • Inflammation / metabolism
  • Male
  • Middle Aged
  • Oxidation-Reduction
  • Synovial Fluid / metabolism*
  • Viscosity


  • Free Radicals
  • Copper