Effect of oral sucrose on blood pressure in the spontaneously hypertensive rat

Metabolism. 1981 May;30(5):421-4. doi: 10.1016/0026-0495(81)90173-6.


In the spontaneously hypertensive rat (SHR) increased carbohydrate intake without alteration in sodium intake is associated with elevated blood pressure. One week of feeding sucrose-supplemented chow increased blood pressure an average of 14mm Hg (9%) in three separate groups of SHR, but did not affect blood pressure in normotensive rats of the same strain (Wistar-Kyoto-WKY). Fat supplementation (isocaloric to sucrose) was without effect on blood pressure in SHR. These data are consistent with the hypothesis that diet-induced increases in sympathetic activity may elevate blood pressure in susceptible animals.

Publication types

  • Comparative Study
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Blood Pressure / drug effects*
  • Body Weight / drug effects
  • Diet
  • Dietary Carbohydrates / pharmacology*
  • Dietary Fats / pharmacology
  • Female
  • Hypertension / physiopathology*
  • Rats
  • Sodium / administration & dosage
  • Sucrose / pharmacology*


  • Dietary Carbohydrates
  • Dietary Fats
  • Sucrose
  • Sodium