Molecular cloning and characterization of cDNA sequences coding for rat relaxin

Nature. 1981 May 14;291(5811):127-31. doi: 10.1038/291127a0.


Using a synthetic oligonucleotide primer, cloned DNA fragments, each containing the entire coding sequence of rat relaxin, have been isolated from a clone 'bank' of ovarian mRNA sequences. The nucleotide sequence of these clones demonstrates that relaxin is synthesized as a preprorelaxin molecule with an unexpectedly large connecting peptide of 105 amino acid residues.

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Cloning, Molecular / methods*
  • Female
  • Genes
  • Ovary / metabolism
  • Pregnancy
  • RNA, Messenger / genetics
  • Rats
  • Relaxin / biosynthesis
  • Relaxin / genetics*


  • RNA, Messenger
  • Relaxin

Associated data

  • GENBANK/J00780