Preservation of the ischaemic canine kidney with inosine

Urol Res. 1981;9(2):75-8. doi: 10.1007/BF00256680.


Direct intra-renal perfusion of inosine was found to protect the canine kidney from 90 min of warm ischaemia. Significantly lower (P less than 0.01) serum creatinine levels were found 24 and 72 h post-operatively in an inosine treated group (N = 12) when compared to a control group (N = 5). Histological examination of the pre-treated kidneys confirmed the protective effect of inosine.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Dogs
  • Inosine / therapeutic use*
  • Ischemia / drug therapy*
  • Kidney / blood supply*
  • Male
  • Organ Preservation / methods*
  • Tissue Preservation / methods*


  • Inosine