Effects of caffeine ingestion on metabolism and exercise performance

Med Sci Sports. Fall 1978;10(3):155-8.


In an effort to assess the effects of caffeine ingestion on metabolism and performance during prolonged exercise, nine competitive cyclists (two females and seven males) exercised until exhaustion on a bicycle ergometer at 80% of Vo2 max. One trial was performed an hour after ingesting decaffeinated coffee (Trial D), while a second trial (C) required that each subject consume coffee containing 330 mg of caffeine 60 min before the exercise. Following the ingestion of caffeine (Trial C), the subjects were able to perform an average of 90.2 (SE +/- 7.2) min of cycling as compared to an average of 75.5 (SE +/- 5.1) min in the D Trial. Measurements of plasma free fatty acids, glycerol and respiratory exchange ratios evidenced a greater rate of lipid metabolism during the caffeine trial as compared to the decaffeinated exercise treatment. Calculations of carbohydrate (CHO) metabolism from respiratory exchange data revealed that the subjects oxidized roughly 240 g of CHO in both trials. Fat oxidation, however, was significantly higher (P less than 0.05) during the C Trial (118 g or 1.31 g/min) than in the D Trial (57 g or 0.75 g/min). On the average the participants rated (Perceived Exertion Scale) their effort during the C Trial to be significantly (P less than 0.05) easier than the demands of the D treatment. Thus, the enhanced endurance performance observed in the C Trial was likely the combined effects of caffeine on lipolysis and its positive influence on nerve impulse transmission.

MeSH terms

  • Adult
  • Blood Glucose / metabolism
  • Caffeine / pharmacology*
  • Fatty Acids, Nonesterified / blood
  • Female
  • Glycerol / blood
  • Glycogen / metabolism
  • Humans
  • Lactates / blood
  • Male
  • Metabolism / drug effects*
  • Physical Exertion / drug effects*
  • Sports Medicine*
  • Triglycerides / blood


  • Blood Glucose
  • Fatty Acids, Nonesterified
  • Lactates
  • Triglycerides
  • Caffeine
  • Glycogen
  • Glycerol