CSF perfusion to treat intraventricular penicillin toxicity

Arch Neurol. 1981 Jun;38(6):390-1. doi: 10.1001/archneur.1981.00510060092022.


A shunt infection and meningitis developed in a patient receiving methotrexate intravenously for CNS leukemia. Convulsions and respiratory failure followed the intraventricular administration of 300,000 units of penicillin G potassium. Perfusion with 900 mL of Ringer's lactate removed an amount of penicillin equal to that injected intraventricularly plus some from systemic treatment.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Cerebrospinal Fluid*
  • Humans
  • Injections, Intraventricular
  • Leukemia / complications
  • Male
  • Meningeal Neoplasms / complications
  • Meningitis / drug therapy
  • Penicillin G / toxicity*
  • Perfusion*


  • Penicillin G