Is glutamate a trigger factor in epileptic hyperactivity?

Epilepsia. 1981 Jun;22(3):289-96. doi: 10.1111/j.1528-1157.1981.tb04112.x.


The effects of glutamate and aspartate antagonists were studied on limb-jerk frequency and EEG patterns in rats made epileptic by cobalt implantation in the sensorimotor cerebral cortex. The results of this study were as follows: (1) alpha-Amino-4-phosphonobutyric acid (0.055--1.10 mM) decreased or completely prevented the epileptic manifestations. The effect was reversible 30 min after washing with artificial CSF solution. (2) DL-Pyroglutamic acid completely abolished the myoclonic jerks and EEG spikes. (3) alpha-Amino-5-phosphonovaleric acid and alpha-D-amino-adipic acid significantly reduced the frequency of epileptic spikes and myoclonic jerks. (4) Other analogs, alpha-amino-3-phosphonopropionic acid (0.6 mM), alpha-amino phosphonocaproic acid (0.95), and hydroxy-3-amino pyrrolidone-2 were without effect. (5) Glutamate itself did not decrease the epileptic manifestations.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amino Acids / analysis
  • Aminobutyrates / pharmacology
  • Animals
  • Aspartic Acid / antagonists & inhibitors
  • Cerebral Cortex / analysis
  • Electroencephalography
  • Epilepsy / etiology*
  • Epilepsy / physiopathology
  • Excitatory Amino Acid Antagonists
  • Female
  • Glutamates / physiology*
  • Organophosphorus Compounds / pharmacology
  • Rats
  • Seizures / etiology


  • Amino Acids
  • Aminobutyrates
  • Excitatory Amino Acid Antagonists
  • Glutamates
  • Organophosphorus Compounds
  • Aspartic Acid
  • 2-amino-4-phosphonobutyric acid