Effects of vitamin D supplementation in pregnancy

Gynecol Obstet Invest. 1981;12(3):155-61. doi: 10.1159/000299597.


Serum calcium, inorganic phosphate and heat-labile alkaline phosphatase (HLAP) have been estimated in maternal and cord sera of 120 pregnant women at labour. 75 women who did not take any vitamin D supplements during pregnancy showed statistically significant hypocalcaemia, hypophosphataemia and elevation of HLAP. Hypocalcaemia and hypophosphataemia were present in cord blood, too. 25 women who had received 1,200 U vitamin D/day throughout the 3rd trimester, showed significantly lower HLAP levels and increased fetal birth weight but there was no other improvement in maternal or cord blood chemistry. Administration of vitamin D in two large doses of 600,000 U each in the 7th and 8th months of pregnancy in 20 women proved more efficacious. Statistically significant improvement was observed in all the three biochemical parameters in maternal as well as cord sera. Fetal birth weight was also significantly greater with this mode of therapy.

MeSH terms

  • Birth Weight / drug effects*
  • Calcium / blood
  • Female
  • Humans
  • Infant, Newborn
  • Phosphates / blood
  • Pregnancy / drug effects*
  • Pregnancy Trimester, Third
  • Vitamin D / administration & dosage*


  • Phosphates
  • Vitamin D
  • Calcium