Genetic toxicological of some plant flavonoids by the micronucleus test

Mutat Res. 1981 May;89(1):69-74. doi: 10.1016/0165-1218(81)90132-4.

Abstract

4 important flavonoid compounds, namely quercetin, kaempferol, neohesperidin dihydrochalcone and rutin, were administered to male mice for the detection of gross chromosomal anomalies by the micronucleus test. The first 3 compounds were positively clastogenic to different extents, whereas the 4th was negative.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Bone Marrow Cells
  • Cell Nucleus / drug effects
  • Cell Nucleus / ultrastructure
  • Chalcone / analogs & derivatives
  • Chalcone / pharmacology
  • Chalcones
  • Erythrocytes / drug effects
  • Flavonoids / pharmacology*
  • Hesperidin / analogs & derivatives
  • Hesperidin / pharmacology
  • Kaempferols*
  • Male
  • Mice
  • Mutagenicity Tests
  • Mutagens*
  • Plants
  • Quercetin / pharmacology
  • Rutin / pharmacology
  • Sweetening Agents / pharmacology

Substances

  • Chalcones
  • Flavonoids
  • Kaempferols
  • Mutagens
  • Sweetening Agents
  • neohesperidin dihydrochalcone
  • Rutin
  • Chalcone
  • kaempferol
  • Quercetin
  • Hesperidin