Abstract
4 important flavonoid compounds, namely quercetin, kaempferol, neohesperidin dihydrochalcone and rutin, were administered to male mice for the detection of gross chromosomal anomalies by the micronucleus test. The first 3 compounds were positively clastogenic to different extents, whereas the 4th was negative.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Bone Marrow Cells
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Cell Nucleus / drug effects
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Cell Nucleus / ultrastructure
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Chalcone / analogs & derivatives
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Chalcone / pharmacology
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Chalcones
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Erythrocytes / drug effects
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Flavonoids / pharmacology*
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Hesperidin / analogs & derivatives
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Hesperidin / pharmacology
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Kaempferols*
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Male
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Mice
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Mutagenicity Tests
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Mutagens*
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Plants
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Quercetin / pharmacology
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Rutin / pharmacology
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Sweetening Agents / pharmacology
Substances
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Chalcones
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Flavonoids
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Kaempferols
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Mutagens
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Sweetening Agents
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neohesperidin dihydrochalcone
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Rutin
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Chalcone
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kaempferol
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Quercetin
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Hesperidin