Colorimetric rate method for the determination of creatinine as implemented by the Beckman Creatinine Analyzer 2

Am J Med Technol. 1980 Nov;46(11):792-8.


We evaluated the performance characteristics of the Beckman Creatinine Analyzer 2, a kinetic colorimetric analyzer which utilizes a modified Jaffé reagent. The instrument gave linear measurements to at least 300 mg/L and its within-run precision on a 50 mg/l creatinine standard was 1.1%. Its between-day precision on the 50 mg/L creatinine standard was less than 5.0%. Its results correlated well with those from the manual Jaffé. CentrifiChem System 400, TechniconTM SMATM 6/60 System, and TraceTM systems I and III. Interferences from 19 possible serum constituents and 32 drugs were almost nonexistent. The extended linear range of the Creatinine Analyzer 2 allowed the direct assay of samples from patients undergoing periodic hemodialysis.

Publication types

  • Comparative Study

MeSH terms

  • Bilirubin / metabolism
  • Colorimetry / instrumentation*
  • Creatinine / blood*
  • Evaluation Studies as Topic
  • Humans
  • Proteins / metabolism


  • Proteins
  • Creatinine
  • Bilirubin