Granulomatous hepatitis secondary to carbamazepine

Ann Intern Med. 1981 Jul;95(1):64-5. doi: 10.7326/0003-4819-95-1-64.


Three cases of carbamazepine-induced granulomatous hepatitis are reported. Each patient had ingested carbamazepine for less than 1 month before presenting with a febrile illness suggestive of biliary tract infection. After withdrawal of carbamazepine, symptoms disappeared rapidly. Histologically, all patients had granulomatous hepatitis. Two patients also had acute cholangitis. Carbamazepine-induced liver injury can be confused clinically and pathologically with biliary tract infection.

Publication types

  • Case Reports

MeSH terms

  • Carbamazepine / adverse effects*
  • Chemical and Drug Induced Liver Injury / etiology*
  • Chemical and Drug Induced Liver Injury / pathology
  • Cholangitis / chemically induced
  • Granuloma / chemically induced
  • Granuloma / pathology
  • Humans
  • Liver / pathology
  • Male
  • Middle Aged


  • Carbamazepine