Antiphosphocholine antibodies found in normal mouse serum are protective against intravenous infection with type 3 streptococcus pneumoniae

J Exp Med. 1981 Mar 1;153(3):694-705. doi: 10.1084/jem.153.3.694.

Abstract

The antiphosphocholine (PC) antibody in normal mouse sera (NMS) provides protection against intravenous infection with encapsulated strain WU2 of type 3 Streptococcus pneumoniae. Mice unable to make anti-PC antibody, as a result of suppression with anti-T-15 idiotype or inheritance of the xid gene of CAB/N mice, are highly susceptible to infection with strain WU2. Mice inheriting the xid gene can be protected with NMS from immunologically normal mice or with IgM hybridoma anti-PC antibody. The protective effect of NMS can be removed with PC-containing immunoabsorbents.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Antibodies*
  • Antibody Formation
  • Antibody Specificity
  • Choline / analogs & derivatives*
  • Crosses, Genetic
  • Female
  • Hybrid Cells / immunology
  • Injections, Intravenous
  • Male
  • Mice
  • Mice, Inbred BALB C
  • Mice, Inbred CBA
  • Mice, Inbred DBA
  • Phosphorylcholine / immunology*
  • Pneumococcal Infections / immunology*
  • Streptococcus pneumoniae / immunology

Substances

  • Antibodies
  • Phosphorylcholine
  • Choline