The use of technetium-99m sulfur colloid as a marker for experimental venous thrombosis: concise communication

J Nucl Med. 1981 Jul;22(7):598-600.


The binding of technetium-99m sulfur colloid to in vivo thrombi was studied in a rat model of deep vein thrombosis. After thrombosis was induced by mechanical traumatization of a right femoral vein segment, technetium-99m sulfur colloid was injected into the peripheral veins of different experimental groups at intervals of 30 min and 1-7 days. Ratios of mean activity in traumatized right femoral vein segment to activity in control segments of left femoral vein (R/L ratios) ranged form 2.97-11.0 for all in situ venous thrombi studied. There was no relation between clot size and R/L ratios. The significant uptake ratios observed by us for venous thrombi up to 1 wk in age suggest that in vivo thrombus detection may be feasible by imaging with a gamma camera after technetium-99m sulfur colloid injection in a peripheral vein.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Colloids*
  • Femoral Vein
  • Male
  • Radionuclide Imaging
  • Rats
  • Sulfur*
  • Technetium Tc 99m Sulfur Colloid
  • Technetium*
  • Thrombophlebitis / diagnostic imaging*
  • Time Factors


  • Colloids
  • Technetium Tc 99m Sulfur Colloid
  • Sulfur
  • Technetium