Experimental model of gyrate atrophy in animals

Ophthalmology. 1981 Apr;88(4):331-5. doi: 10.1016/s0161-6420(81)35027-1.


Intravitreal injection of L-ornithine hydrochloride in physiologic saline solution caused marked edema specifically in the pigment epithelium of Sprague-Dawley strain albino and Evans black hooded rats and rhesus and cynomologus monkeys. Swelling of the pigment epithelial cells, which was most prominent four hours after the injection, disappeared by 24 hours. However, many pigment epithelial cells gradually degenerated resulting in patches of denuded areas. The photoreceptor cells overlying the damaged pigment epithelium degenerated secondarily.

MeSH terms

  • Animals
  • Atrophy / chemically induced
  • Choroid*
  • Disease Models, Animal*
  • Injections
  • Macaca fascicularis
  • Macaca mulatta
  • Ornithine
  • Pigment Epithelium of Eye / drug effects
  • Rats
  • Rats, Inbred Strains
  • Retinal Degeneration / chemically induced
  • Retinal Degeneration / genetics*
  • Uveal Diseases / chemically induced
  • Uveal Diseases / genetics
  • Vitreous Body


  • Ornithine