Effect of exogenous hyaluronic acid on joint function in experimentally induced equine osteoarthritis: dosage titration studies

Res Vet Sci. 1981 Mar;30(2):192-7.


A single intra-articular injection of 20 or 40 mg of purified hyaluronic acid of rooster comb origin resulted in restoration of normal joint function in horses with experimentally induced osteoarthritis. The functional improvement, measured by pressure sensitive force plate techniques, was detectable within one week after treatment and persisted throughout a four week experimental period despite continued use of the joints. The response was dose dependent in that injection of 0 (saline), 5 or 10 mg hyaluronic acid per joint space resulted in no significant change in joint function while dosages of 20 or 40 mg produced maximum improvement.

Publication types

  • Comparative Study

MeSH terms

  • Animals
  • Biomechanical Phenomena
  • Female
  • Horse Diseases / drug therapy*
  • Horse Diseases / physiopathology
  • Horses
  • Hyaluronic Acid / administration & dosage*
  • Hyaluronic Acid / therapeutic use
  • Injections, Intra-Articular
  • Joints / physiopathology*
  • Male
  • Osteoarthritis / drug therapy
  • Osteoarthritis / physiopathology
  • Osteoarthritis / veterinary*


  • Hyaluronic Acid