Streptomycin ototoxicity in the unborn child

S Afr Med J. 1981 Aug 22;60(8):316-8.


Streptomycin has been used in pregnant patients for more than 30 years. Some doubt, however, still exists with regard to its effects on the ear of the unborn child. Thirty-three children whose mothers had received streptomycin during pregnancy were followed up and their hearing tested. A minor degree of hearing loss which could possible be due to the action of streptomycin was found in only 2 children.

MeSH terms

  • Female
  • Fetus / drug effects*
  • Follow-Up Studies
  • Hearing Loss / chemically induced*
  • Hearing Loss, High-Frequency / chemically induced*
  • Hearing Loss, Sensorineural / chemically induced*
  • Humans
  • Pregnancy
  • Pregnancy Complications, Infectious / drug therapy*
  • Streptomycin / adverse effects*
  • Tuberculosis, Pulmonary / drug therapy*


  • Streptomycin