[Effect of ethionamide and sodium succinate on NADPH-dependent oxidaton in the liver]

Ukr Biokhim Zh (1978). 1980 Sep-Oct;52(5):593-6.
[Article in Russian]

Abstract

A single administration of ethionamide (LD50) to guinea pigs causes an inhibition of p-hydroxylation and N-demethylation in the liver. Sodium succinate favours the activation and, when it is used for correction of the ethionamide toxic effect, it normalizes the above-mentioned processes.

Publication types

  • English Abstract

MeSH terms

  • Animals
  • Ethionamide / pharmacology*
  • Guinea Pigs
  • Hydroxylation
  • Kinetics
  • Liver / drug effects
  • Liver / metabolism*
  • NADP / metabolism*
  • Oxidation-Reduction
  • Succinates / pharmacology*

Substances

  • Succinates
  • NADP
  • Ethionamide