[Vitamin B12-level in serum of diabetics receiving long-term buformin therapy]

Z Gesamte Inn Med. 1981 Mar 15;36(6):226-8.
[Article in German]


Disturbances of the vitamin B12 resorption by the therapy with biguanides above all metformin are known from literature. In 59 patients with Buformin retard-monotherapy we determined in 18.7% slight reductions of the vitamin B12 level in the serum, in one patient the serum concentration was lower than 50 pg/ml. That means that also under therapy with Buformin can be reckoned with easy disturbances of resorption for vitamin B12. Occasional controls of Hb and anamnestic establishment of neurological symptoms are to be recommended during a therapy with Buformin, in order not to overlook the clinical signs of a vitamin B12 hypovitaminosis.

Publication types

  • English Abstract

MeSH terms

  • Biguanides / adverse effects*
  • Buformin / adverse effects*
  • Buformin / therapeutic use
  • Diabetes Mellitus / drug therapy
  • Female
  • Humans
  • Intestinal Absorption / drug effects
  • Male
  • Vitamin B 12 / blood
  • Vitamin B 12 Deficiency / chemically induced


  • Biguanides
  • Vitamin B 12
  • Buformin