CSF GABA in normal subjects and patients with depression, schizophrenia, mania, and anorexia nervosa

Am J Psychiatry. 1981 Aug;138(8):1098-101. doi: 10.1176/ajp.138.8.1098.


The authors examined the CSF GABA of 87 subjects: 29 normal control subjects, 11 patients with schizophrenia, 26 with depression, 6 with mania, and 15 with anorexia nervosa. Depressed patients had significantly lower CSF GABA levels than did normal subjects. This finding suggests that GABA may have a direct or indirect association with depressive affective disorders.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Adolescent
  • Adult
  • Affective Disorders, Psychotic / cerebrospinal fluid*
  • Aged
  • Anorexia Nervosa / cerebrospinal fluid*
  • Bipolar Disorder / cerebrospinal fluid*
  • Depressive Disorder / cerebrospinal fluid*
  • Female
  • Humans
  • Male
  • Middle Aged
  • Schizophrenia / cerebrospinal fluid*
  • Sex Factors
  • gamma-Aminobutyric Acid / cerebrospinal fluid*


  • gamma-Aminobutyric Acid