The interaction of transport and metabolism on brain glucose utilization: a reevaluation of the lumped constant

J Neurochem. 1981 Apr;36(4):1601-4. doi: 10.1111/j.1471-4159.1981.tb00607.x.


The relative cerebral cortical metabolism of glucose (GLU) and 2-deoxy-D-glucose (DG) was measured in vivo in control and insulin-treated hypoglycemic rats. The ratio of the utilization rate constants for the two hexoses, i.e., KDG/KGLU is defined as the Hexose Utilization Index (HUI). The HUI was found to be invariant in rats whose cerebral glucose content exceeded 1 mumol . g-1 wet weight (HUI = 0.48 +/- 0.07). Severe hypoglycemia (plasma glucose less than 2 mM) effected a shift in the HUI to 1.04 +/- 0.21. The results are consistent with a model in which the interpretation of the HUI is determined by the rate of transport into brain, or subsequent phosphorylation, as the rate-limiting step for hexose utilization.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Biological Transport
  • Blood-Brain Barrier
  • Brain / metabolism*
  • Deoxyglucose / metabolism
  • Glucose / metabolism*
  • Hexokinase / metabolism
  • Hypoglycemia / metabolism
  • Kinetics
  • Male
  • Rats


  • Deoxyglucose
  • Hexokinase
  • Glucose