Inhibition of hepatic cholesterol biosynthesis by chloroquine

Lipids. 1981 Jun;16(6):472-4. doi: 10.1007/BF02535017.

Abstract

Chloroquine is shown to be a potent inhibitor of cholesterol biosynthesis by isolated rat hepatocytes. Half-maximal inhibition of cholesterogenesis occurs at ca. 10 micro M chloroquine. Chloroquine does not affect fatty acid synthesis by isolated hepatocytes. This suggests that chloroquine acts on the cholesterol biosynthetic pathway beyond the cytosolic acetyl-coA branchpoint of cholesterol and fatty acid synthesis.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Anticholesteremic Agents
  • Chloroquine / pharmacology*
  • Cholesterol / biosynthesis*
  • Dose-Response Relationship, Drug
  • Fatty Acids / biosynthesis
  • Liver / cytology
  • Liver / metabolism*
  • Male
  • Rats

Substances

  • Anticholesteremic Agents
  • Fatty Acids
  • Chloroquine
  • Cholesterol