The authors present the development of a intrahepatic Cholestasis in a Hodgkin's disease. The cholestasis was characterized with the biochemical signs of total bile duct obstruction. There were also signs of cholestasis at liver biopsy, while non hepatic involvement was detected. No biliary tract obstruction was proved. Chemotherapy produced remission of cholestasis. They also went over the different theories on the etiology and physiopathogeny of the idiopathic cholestasis in this disease, which are still uncertain, and they especially remark the need of discarding the idiopatic cholestasis in a Hodgkin's disease with jaundice.