Wheat gluten challenge in schizophrenic patients

Am J Psychiatry. 1981 Sep;138(9):1208-11. doi: 10.1176/ajp.138.9.1208.


Eight chronic schizophrenic patients were maintained on a diet free of gluten, cereal grains, and milk (CM-F diet) and challenged in a double-blind manner with dietary wheat gluten and placebo. While on the CM-F diet, each patient received a daily challenge of 30 g of gluten for 5 weeks and a placebo challenge for 8 weeks. No deterioration in clinical status as measured by the BPRS was noted on gluten challenge. Serum alpha 1 acid glycoprotein measurement demonstrated no evidence of inflammatory response to gluten challenge. The data suggest that sensitivity to dietary gluten is not characteristic of young chronic schizophrenic patients.

MeSH terms

  • Adult
  • Double-Blind Method
  • Female
  • Glutens / administration & dosage
  • Glutens / adverse effects*
  • Humans
  • Male
  • Orosomucoid / blood
  • Psychiatric Status Rating Scales
  • Schizophrenia / diet therapy*
  • Schizophrenia / etiology
  • Triticum


  • Orosomucoid
  • Glutens