Intranasal vaccination of dogs with liver avirulent Bordetella bronchiseptica: correlation of serum agglutination titer and the formation of secretory IgA with protection against experimentally induced infectious tracheobronchitis

Am J Vet Res. 1981 Jul;42(7):1130-2.

Abstract

Dogs inoculated intranasally with a live avirulent Bordetella bronchiseptica vaccine were monitored for the development of resistance to experimentally induced infectious tracheobronchitis (canine cough). Dogs were challenge exposed with a virulent strains of B bronchiseptica at various times after they were vaccinated. Clinical protection was detectable as early as 48 hours. At postvaccination days 4, 5, and 14, 56%, 83%, and 95% protection was observed. Humoral immunoglobulin (Ig) titers ranged from 1:8.6 on day 0 to 1:147 on postvaccination day 21. In the monitoring of B bronchiseptica-specific secretory IgA by indirect immunofluorescence, titers appeared as early as day 4 after vaccination. The IgA titers ranged from 1:16 on day 4 to 1: 1,024 on day 21. The appearance of IgA titers correlated with the development of resistance to clinical infection.

MeSH terms

  • Administration, Intranasal
  • Animals
  • Bacterial Vaccines / administration & dosage
  • Bacterial Vaccines / immunology*
  • Bordetella / immunology*
  • Bordetella Infections / prevention & control
  • Bordetella Infections / veterinary*
  • Bronchitis / prevention & control
  • Bronchitis / veterinary*
  • Dog Diseases / prevention & control*
  • Dogs
  • Immunoglobulin A / biosynthesis*
  • Immunoglobulin A, Secretory / biosynthesis*
  • Immunoglobulins / biosynthesis
  • Tracheitis / prevention & control
  • Tracheitis / veterinary*
  • Vaccines, Attenuated / administration & dosage
  • Vaccines, Attenuated / immunology

Substances

  • Bacterial Vaccines
  • Immunoglobulin A
  • Immunoglobulin A, Secretory
  • Immunoglobulins
  • Vaccines, Attenuated