Cytotoxicity and mutagenicity of the fungicides captan and folpet in cultured mammalian cells CHO/HGPRT system)

Environ Mutagen. 1981;3(3):233-7. doi: 10.1002/em.2860030306.

Abstract

The cytotoxicity and mutagenicity of the fungicides captan and folpet were determined in the CHO/HGPRT system which utilizes Chinese hamster ovary cells and resistance to 6-thioguanine to estimate mutation induction at the hypoxanthine-guanine phosphoribosyl transferase locus. Treatment of cultures with each compound for 5 hr is serum-free medium resulted in reproducible, significant, concentration-dependent increase in the frequency of 6-thioguanine-resistant mutants.

Publication types

  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Animals
  • Captan / toxicity*
  • Cell Survival / drug effects*
  • Cells, Cultured
  • Colony-Forming Units Assay
  • Cricetinae
  • Female
  • Fungicides, Industrial / toxicity*
  • Hypoxanthine Phosphoribosyltransferase / genetics
  • Mutagens*
  • Phthalimides / toxicity*

Substances

  • Fungicides, Industrial
  • Mutagens
  • Phthalimides
  • Hypoxanthine Phosphoribosyltransferase
  • Captan
  • folpet