A stem-line model for cellular and chromosomal differentiation in early mouse-development

Differentiation. 1981;19(2):71-6. doi: 10.1111/j.1432-0436.1981.tb01131.x.


Differentiation in mouse embryo development is represented formally by means of a stem-line model in which: 1. Individual choices are structured so that only a fraction of the cells of a given population receive a signal to undergo a change of state that results in a departure from the stem line. 2. Development proceeds by a series of restrictions in potency of all the cells in the stem line. 3. The stem line harbours the germ cells. 4. The germ cells are returned to a state of totipotency by some event(s) leading to meiosis.

MeSH terms

  • Animals
  • Blastomeres / cytology
  • Cell Differentiation*
  • Ectoderm / cytology
  • Embryo, Mammalian / cytology*
  • Endoderm / cytology
  • Female
  • Germ Cells / cytology*
  • Male
  • Meiosis
  • Mice
  • Models, Biological*
  • Sex Chromosomes / physiology*
  • Teratoma / etiology
  • Trophoblasts / cytology
  • X Chromosome / physiology*