Abstract
A new electrophoretically silent, unstable hemoglobin was discovered in a Japanese family. Isolation of the abnormal chain and chemical analyses demonstrated a previously unreported amino acid substitution, alpha 59[E8] glycine replaced by Valine. The new variant has been named Hb Tottori.
Publication types
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Case Reports
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Research Support, Non-U.S. Gov't
MeSH terms
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Adult
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Drug Stability
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Erythrocytes / ultrastructure
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Female
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Genetic Variation
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Glycine*
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Hemoglobins, Abnormal / genetics*
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Humans
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Male
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Microscopy, Electron, Scanning
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Pedigree
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Valine*
Substances
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Hemoglobins, Abnormal
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hemoglobin Tottori
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Valine
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Glycine