Hemoglobin Tottori (alpha 59[E8] glycine replaced by valine)

Hemoglobin. 1981;5(5):427-39. doi: 10.3109/03630268108991818.

Abstract

A new electrophoretically silent, unstable hemoglobin was discovered in a Japanese family. Isolation of the abnormal chain and chemical analyses demonstrated a previously unreported amino acid substitution, alpha 59[E8] glycine replaced by Valine. The new variant has been named Hb Tottori.

Publication types

  • Case Reports
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Drug Stability
  • Erythrocytes / ultrastructure
  • Female
  • Genetic Variation
  • Glycine*
  • Hemoglobins, Abnormal / genetics*
  • Humans
  • Male
  • Microscopy, Electron, Scanning
  • Pedigree
  • Valine*

Substances

  • Hemoglobins, Abnormal
  • hemoglobin Tottori
  • Valine
  • Glycine