Gilvocarcins, new antitumor antibiotics. 1. Taxonomy, fermentation, isolation and biological activities

J Antibiot (Tokyo). 1981 Mar;34(3):266-70. doi: 10.7164/antibiotics.34.266.

Abstract

Gilvocarcin V and gilvocarcin M, a group of antitumor antibiotics with a novel skeleton, were discovered in culture broths of Actinomycete DO-38. The producing organism, subsequently determined to be a new species and named Streptomyces gilvotanareus (NRRL 11382). Gilvocarcin V and M were isolated by ethyl acetate extraction and chromatography on silica gel. The antibiotics are active against Gram-positive bacteria and experimental tumors such as mouse sarcoma 180 and mouse leukemia P388.

MeSH terms

  • Actinomyces / classification
  • Actinomyces / physiology
  • Aminoglycosides*
  • Animals
  • Anti-Bacterial Agents*
  • Antibiotics, Antineoplastic / isolation & purification*
  • Antibiotics, Antineoplastic / pharmacology
  • Coumarins
  • Fermentation
  • Glycosides / isolation & purification
  • Glycosides / pharmacology
  • Mice

Substances

  • Aminoglycosides
  • Anti-Bacterial Agents
  • Antibiotics, Antineoplastic
  • Coumarins
  • Glycosides
  • gilvocarcin M
  • gilvocarcin V