M-Currents in voltage-clamped mammalian sympathetic neurones

Neurosci Lett. 1981 Jul 17;24(3):289-94. doi: 10.1016/0304-3940(81)90173-7.


The M-current (IM), a species of time- and voltage-dependent K+-current previously identified in amphibian sympathetic neurones, has been detected in voltage-clamped rat sympathetic neurone somata. IM had an activation threshold of about -70 mV and, since it did not show time-dependent inactivation, contributed an increasing outward component to the steady membrane current between -70 and -20 mV. Selective inhibition of IM by muscarine or by angiotensin-II probably accounts for the membrane depolarization produced by these two agonists on rat ganglia.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Angiotensin II / pharmacology
  • Animals
  • Electric Conductivity
  • Ganglia, Sympathetic / drug effects
  • Ganglia, Sympathetic / physiology*
  • Membrane Potentials
  • Muscarine / pharmacology
  • Neurons / drug effects
  • Neurons / physiology*
  • Potassium / pharmacology
  • Rats


  • Angiotensin II
  • Muscarine
  • Potassium