Human Prostatic Adenocarcinoma: Some Characteristics of a Serially Transplantable Line in Nude Mice (PC 82)

Prostate. 1980;1(1):95-104. doi: 10.1002/pros.2990010113.

Abstract

Transplantation of tissue from a cribriform human prostatic carcinoma resulted in a serially transplantable tumor line in nude mice, PC 82. During 2 1/2 years the tumor has not changed its histological appearance and remained a moderately differentiated adenocarcinoma. The cells contain large amounts of prostatic acid phosphatase. It has a slow rate of growth and regresses after castration and estrogen treatment. This preliminary information suggests that the PC 82 tumor line may be suitable model for hormone-dependent human prostatic cancer.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Acid Phosphatase / analysis
  • Adenocarcinoma / surgery*
  • Animals
  • Castration
  • Cell Division
  • Estradiol / pharmacology
  • Female
  • Humans
  • Male
  • Mice
  • Mice, Nude
  • Microscopy, Electron
  • Middle Aged
  • Prostatic Neoplasms / surgery*
  • Transplantation, Heterologous

Substances

  • Estradiol
  • Acid Phosphatase