Alloxane diabetes in rats was accompanied by a distinct increase in total content of phospholipids and their fractions (especially of acid phospholipids) in whole blood; the ratio of neutral phospholipids/acid phospholipids was decreased. Content of phospholipids was distinctly normalized in rat blood after intramuscular administration of Bryonia alba extract into the diabetic animals at a dose of 0.5 mg/100 g of body mass.