Effects of high oxygen tension on the metabolism of vasoactive hormones in isolated perfused rat lungs

Acta Physiol Scand. 1981 Feb;111(2):185-92. doi: 10.1111/j.1748-1716.1981.tb06723.x.


The effect of exposure of rats to high concentrations of oxygen (90-95%, normobaric) on the activation of angiotensin I to angiotensin II and on the inactivation of bradykinin, prostaglandin E2 (PGE2) and 5-hydroxytryptamine (serotonin) in the pulmonary circulation of isolated perfused rat lungs was investigated. After 36 h exposure, PGE2 survival in the pulmonary circulation increased and reached 3 times the control value after 48 h exposure. A decrease in the conversion of angiotensin I to angiotensin II was seen after 48 h exposure. No decrease in the inactivation of 5-hydroxytryptamine was seen until after 60 h exposure. At this time bradykinin inactivation was also decreased. The decrease in metabolism of angiotensin I and PGE2 following 48 h exposure to oxygen was reversed by a subsequent exposure to room air for 12 h. In these experiments, therefore, the earliest sign of oxygen toxicity was a decrease in PGE2 metabolism, a reaction associated with cells other than endothelial cells.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Angiotensin I / metabolism*
  • Angiotensin II / metabolism*
  • Angiotensins / metabolism*
  • Animals
  • Bradykinin / metabolism*
  • Lung / metabolism*
  • Male
  • Oxygen / pharmacology*
  • Perfusion
  • Prostaglandins E / metabolism*
  • Pulmonary Circulation
  • Rats
  • Rats, Inbred Strains
  • Serotonin / metabolism*
  • Time Factors


  • Angiotensins
  • Prostaglandins E
  • Angiotensin II
  • Serotonin
  • Angiotensin I
  • Oxygen
  • Bradykinin