[Pharmacokinetics and antiviral activity of riodoksol in an ointment and in ophthalmic drug films in ocular herpes]

Abstract

A study was made on the pharmacokinetics in rabbit eye tissues of a new antiviral drug riodoksol in the form of ointment and biosoluble eye films. The pharmacokinetics of the drug was studied in eye tissues of normal rabbits and in those infected with herpes simplex virus. It was disclosed that four-fold application of 0.25% ointment produced the therapeutic concentration of the drug only in the cornea. Application of eye films made it possible to attain the therapeutic concentrations of riodoksol in the cornea and, within the first 3 hours, in the iris and humor of the anterior chamber. No differences were found in the drug concentrations in the tissues of intact and infected animals. Appraisal of the therapeutic efficacy of riodoksol regimens devised in experimental surface herpetic keratitis of rabbits has shown an adequacy of a single administration of eye films containing 0.5 mg of the substance and four-fold application of 0.25% ointment.