Effect of gastric inhibitory polypeptide on plasma levels of chylomicron triglycerides in dogs

J Clin Invest. 1981 Oct;68(4):1106-7. doi: 10.1172/jci110335.


To determine whether gastric inhibitory polypeptide (GIP) promotes the clearance of chylomicron triglycerides (TG) from the circulation in dogs, chyle collected from donor dogs via a thoracic duct fistula was infused at a rate of 2 ml/min i.v. into normal recipient dogs during an infusion of either porcine GIP (1 microgram/kg per h) or saline as a control. In the GIP-infused dogs the rise in plasma TG was significantly below that of the control animals [mean peak of 36 +/- 4 mg/dl vs. 82 +/- 18 mg/dl (P less than 0.05)]. It is concluded that GIP exerts an effect upon the removal of chylomicron TG from the blood. The results suggest that GIP may play a physiologic role in the disposition of ingested fat.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Chylomicrons / blood*
  • Dogs
  • Gastric Inhibitory Polypeptide / pharmacology*
  • Gastrointestinal Hormones / pharmacology*
  • Metabolic Clearance Rate / drug effects
  • Triglycerides / blood*


  • Chylomicrons
  • Gastrointestinal Hormones
  • Triglycerides
  • Gastric Inhibitory Polypeptide