Management of asymptomatic hyperuricemia

JAMA. 1981 Nov 13;246(19):2215-6.


Although the incidence of gout, renal stones, or both is increased in patients with hyperuricemia, there is no evidence that long-term therapy offers any substantial long-term benefits. Recent data also suggest that no clear relationship exists between hyperuricemia and the development of interstitial nephritis (so-called urate nephropathy). Finally, the relationship between elevations in the serum concentration of uric acid and the risk of developing cardiovascular disease remains undefined. It is recommended that, in a patient with asymptomatic hyperuricemia, a conservative approach be taken and hypouricemic therapy not be instituted as a matter of routine.

MeSH terms

  • Acute Disease
  • Cardiovascular Diseases / etiology
  • Decision Making
  • Gout / drug therapy
  • Gout / etiology
  • Humans
  • Kidney Calculi / drug therapy
  • Kidney Calculi / etiology
  • Risk
  • Uric Acid / blood*
  • Uricosuric Agents / therapeutic use*


  • Uricosuric Agents
  • Uric Acid