Genetic analysis of renal function in mice. 1. Glomerular filtration rate and its correlation with body and kidney weight

Lab Anim. 1981 Jul;15(3):267-72. doi: 10.1258/002367781780893731.


Investigation of 18 inbred and 6 F1 hybrid mouse strains has shown that the glomerular filtration rate, bodyweight and kidney weight showed strain- and sex-dependent differences. Covariance analysis showed stronger correlations (genetic and environmental) between glomerular filtration rate and bodyweight than between glomerular filtration rate and kidney weight. This was predominantly due to a high within-strain variation of kidney weight (56%) in male mice. Therefore an allometric regression was calculated between the 48 strain means of glomerular filtration rate (GFR) and bodyweight (BW): GFR = 0.036 x BW0.74. Thus the term BW0.74, a suitable correction term for comparing the heat production of different species, is also suitable for the correction of glomerular filtration rate within one species.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Analysis of Variance
  • Animals
  • Animals, Laboratory
  • Body Weight*
  • Environment
  • Female
  • Glomerular Filtration Rate / veterinary*
  • Hybridization, Genetic
  • Kidney / anatomy & histology*
  • Male
  • Mice
  • Mice, Inbred Strains / anatomy & histology
  • Mice, Inbred Strains / genetics
  • Mice, Inbred Strains / physiology*
  • Organ Size
  • Sex Factors