Production of experimental occlusive myocardial infarction in mice

Cor Vasa. 1978;20(4):308-14.


A method is described for production of occlusive myocardial infarction in mice. The dynamics of development as well as the morphological changes in ischaemized myocardium of mice, large laboratory animals, and humans were identical. Polarization microscopy helped reveal myocardiocytic changes in the ischaemic zone already within the first minutes after coronary artery ligation. The method reported upon has the following advantages: feasibility of all stages of the operation by a single operator, low postoperative mortality of the animals and their modest requirements for postoperative care, and low consumption of isotopes and costly therapeutic remedies.

MeSH terms

  • Animals
  • Coronary Vessels / surgery
  • Disease Models, Animal*
  • Ligation
  • Male
  • Mice*
  • Myocardial Infarction / etiology*
  • Myocardial Infarction / pathology
  • Myocardium / pathology